Impaired skeletal muscle blood flow control with advancing age in humans: attenuated ATP release and local vasodilation during erythrocyte deoxygenation.

Clinical/Translational Research Impaired Skeletal Muscle Blood Flow Control With Advancing Age in Humans Attenuated ATP Release and Local Vasodilation During Erythrocyte Deoxygenation

Skeletal muscle vasodilation during systemic hypoxia in humans.

In humans, the net effect of acute systemic hypoxia in quiescent skeletal muscle is vasodilation despite significant reflex increases in muscle sympathetic vasoconstrictor nerve activity. This vasodilation increases tissue perfusion and oxygen delivery to maintain tissue oxygen consumption. Although several mechanisms may be involved, we recently tested the roles of two endothelial-derived subs...

The age-old tale of skeletal muscle vasodilation: new ideas regarding erythrocyte dysfunction and intravascular ATP in human physiology.

The Age-Old Tale of Skeletal Muscle Vasodilation: New Ideas Regarding Erythrocyte Dysfunction and Intravascular ATP in Human Physiology To the Editor: We are honored that Circulation Research highlighted our recent investigation1 with a companion Editorial article by Dr Chilian and colleagues.2 This undoubtedly will bring further attention to the significant and assorted cardiovascular dysfunct...

Folic acid ingestion improves skeletal muscle blood flow during graded handgrip and plantar flexion exercise in aged humans.

Skeletal muscle blood flow is attenuated in aged humans performing dynamic exercise, which is due, in part, to impaired local vasodilatory mechanisms. Recent evidence suggests that folic acid improves cutaneous vasodilation during localized and whole body heating through nitric oxide-dependent mechanisms. However, it is unclear whether folic acid improves vasodilation in other vascular beds dur...

Mechanical effects of muscle contraction increase intravascular ATP draining quiescent and active skeletal muscle in humans.

Intravascular adenosine triphosphate (ATP) evokes vasodilation and is implicated in the regulation of skeletal muscle blood flow during exercise. Mechanical stresses to erythrocytes and endothelial cells stimulate ATP release in vitro. How mechanical effects of muscle contractions contribute to increased plasma ATP during exercise is largely unexplored. We tested the hypothesis that simulated m...